CAY10471, CRTH2/DP2 antagonist (ab144459)
Key features and details
- Highly potent, selective CRTH2/DP2 antagonist
- CAS Number: 627865-18-3
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CAY10471, CRTH2/DP2 antagonist -
Description
Highly potent, selective CRTH2/DP2 antagonist -
Biological description
Highly potent, selective CRTH2/DP2 antagonist (Ki values are 0.6, 1200 and 10,000 nM for DP2, DP1 and TP respectively). BAY-u3405 (ab142763) analog. Shows renoprotective effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
627865-18-3 -
Chemical structure
Properties
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Chemical name
2-[3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid -
Molecular weight
416.47 -
Molecular formula
C21H21FN2O4S -
PubChem identifier
11384493 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C1CCC2=C(C1)C3=CC=CC=C3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F -
Source
Synthetic
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Research areas