Carbenoxolone disodium salt, Panx1 hemichannel inhibitor (ab143590)
Key features and details
- Selective Panx1 hemichannel inhibitor
- CAS Number: 7421-40-1
- Purity: > 97%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Carbenoxolone disodium salt, Panx1 hemichannel inhibitor -
Description
Selective Panx1 hemichannel inhibitor -
Biological description
Selective Panx1 hemichannel inhibitor. HSP inducer. Reduces COX-2, iNOS, and NF-κB expression. Reduces oxidative stress and shows anti-inflammatory effects in vivo. Orally active. -
Purity
> 97% -
CAS Number
7421-40-1 -
Chemical structure
Properties
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Chemical name
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate disodium salt -
Molecular weight
614.70 -
Molecular formula
C34H48Na2O7 -
PubChem identifier
636402 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+] -
Source
Synthetic
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Research areas