Buparlisib (BKM120) (ab273384)
Key features and details
- In vitro PI3K inhibitor, in vivo tumor growth inhibitor
- CAS Number: 944396-07-0
- Purity: > 95%
Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Buparlisib (BKM120) -
Description
In vitro PI3K inhibitor, in vivo tumor growth inhibitor -
Alternative names
- NVP-BKM120
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Biological description
Potent class I PI3K inhibitor, blocking both p110α and p110β (IC50 = 52 nM and 166 nM, respectively) in vitro. At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth in vivo. Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).
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Purity
> 95% -
General notes
Protect from air.
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CAS Number
944396-07-0 -
Chemical structure
Properties
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Chemical name
5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine
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Molecular weight
410.39 -
Molecular formula
C18H21F3N6O2 -
PubChem identifier
16654980 -
Storage instructions
Shipped at 4°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM
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Handling
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4 -
Source
Synthetic
Images
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Chemical Structure - Buparlisib (BKM120) (ab273384)
Chemical structure of Buparlisib (BKM120), 944396-07-0