Brilliant Blue G, noncompetitive P2X7 antagonist (ab120389)
Key features and details
- Potent, noncompetitive P2X7 antagonist
- CAS Number: 6104-58-1
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Brilliant Blue G, noncompetitive P2X7 antagonist -
Description
Potent, noncompetitive P2X7 antagonist -
Alternative names
- Acid blue 90
- Coomassie® Brilliant Blue G
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Biological description
Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.
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CAS Number
6104-58-1 -
Chemical structure
Properties
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Chemical name
N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt -
Molecular weight
854.02 -
Molecular formula
C47H48N3NaO7S2 -
PubChem identifier
61363 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC -
Source
Synthetic
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Research areas
