BMS-833923, smoothened antagonist (ab269875)
Key features and details
- Potent Smoothened antagonist
- CAS Number: 1059734-66-5
Soluble in water to 5 mM, in DMSO to 100 mM and in ethanol to 10 mM (with warming and ultrasonic)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMS-833923, smoothened antagonist -
Description
Potent Smoothened antagonist -
Biological description
Potent Smoothened antagonist (IC50 = 5.8 nM). Blocks Hedgehog signaling in cell-based assays. Inhibits Gli1 and PTCH1 expression in cell lines. Reduces proliferation and induces apoptosis in tumor cellls.
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CAS Number
1059734-66-5 -
Chemical structure
Properties
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Chemical name
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2- quinazolinyl)amino]benzamide
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Molecular weight
473.57 -
Molecular formula
C30H27N5O -
PubChem identifier
57662985 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in water to 5 mM, in DMSO to 100 mM and in ethanol to 10 mM (with warming and ultrasonic)
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5 -
Source
Synthetic
Images
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Chemical Structure - BMS-833923, smoothened antagonist (ab269875)
Chemical structure of BMS-833923, smoothened antagonist, 1059734-66-5