BMS-708163 (Avagacestat) (ab254245)
Key features and details
- Potent, selective γ-secretase inhibitor
- CAS Number: 1146699-66-2
- Purity: > 98%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMS-708163 (Avagacestat) -
Description
Potent, selective γ-secretase inhibitor -
Alternative names
- (2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide
- Avagacestat
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Biological description
Potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively, compared to IC50 values of 41, 10, 33, and 38 nM respectively for signaling inhibition of the human Notch 1-4 proteins.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
1146699-66-2 -
Chemical structure
Properties
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Chemical name
(2R)-2-[(4-Chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
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Molecular weight
520.88 -
Molecular formula
C20H17ClF4N4O4S -
PubChem identifier
46883536 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl -
Source
Synthetic
