Biotin Anti-C5b-9 + C5b-8 antibody [aE11] (ab237699)
Key features and details
- Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8
- Reacts with: Horse, Human, Pig, Baboon
- Conjugation: Biotin
- Isotype: IgG2a
Overview
-
Product name
Biotin Anti-C5b-9 + C5b-8 antibody [aE11] -
Description
Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8 -
Host species
Mouse -
Conjugation
Biotin -
Specificity
ab237699 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive).
The aE11 monoclonal was first reported to bind to a neoepitope exposed on polymerized C9 when incorporated into the human terminal complement complex (PubMed ID: 4035298). It was subsequently shown that this antibody also cross reacts with the C5b-8 complex and purified C8 alpha-gamma. It does not react with native C9 or C8 proteins (PubMed ID: 2424021).
-
Species reactivity
Reacts with: Horse, Human, Pig, Baboon -
Immunogen
Full length native protein (purified) corresponding to Human C5b-9.
Database link: P01031 -
Epitope
ab237699 binds to a neoepitope exposed on C9.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.0975% Sodium azide
Constituents: 0.16% Sodium phosphate, 0.81% Sodium chloride -
Concentration information loading... -
Purity
Affinity purified -
Purification notes
Biotinylated -
Clonality
Monoclonal -
Clone number
aE11 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
