BI-D1870, RSK Inhibitor (ab254451)
Key features and details
- Cell-permeable, ATP-competitive RSK inhibitor
- CAS Number: 501437-28-1
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BI-D1870, RSK Inhibitor -
Description
Cell-permeable, ATP-competitive RSK inhibitor -
Biological description
Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC50 = 31 nM; RSK2 IC50 = 24 nM; RSK3 IC50 = 18 nM; RSK4 IC50 = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1/CIP1 pathways.
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Purity
> 98% -
General notes
Solutions in DMSO may be stored at -20°C for up to 1 month.
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CAS Number
501437-28-1 -
Chemical structure
Properties
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Chemical name
2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
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Molecular weight
391.40 -
Molecular formula
C19H23F2N5O2 -
PubChem identifier
25023738 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Refer to SDS for more information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C -
Source
Synthetic
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Research areas
