Bay 61-3606 hydrochloride, Syk kinase inhibitor (ab142106)
Key features and details
- Potent, selective, cell-permeable Syk kinase inhibitor
- CAS Number: 732938-37-8
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bay 61-3606 hydrochloride, Syk kinase inhibitor -
Description
Potent, selective, cell-permeable Syk kinase inhibitor -
Biological description
Potent, selective, cell permeable Syk kinase inhibitor (Ki value = 7.5 nM). Inhibits degranulation in vitro (IC50 = 10 nM). Anti-inflammatory. Orally active. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
732938-37-8 -
Chemical structure
Properties
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Chemical name
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride -
Molecular weight
426.86 -
Molecular formula
C20H18N6O3.HCl -
PubChem identifier
52949496 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl -
Source
Synthetic
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Research areas
