AZD6244, MEK1/2 inhibitor (ab141343)
Key features and details
- Potent, selective MEK1/2 inhibitor
- CAS Number: 606143-52-6
- Purity: > 99%
Soluble in DMSO to 100 mM and ethanol 4 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AZD6244, MEK1/2 inhibitor -
Description
Potent, selective MEK1/2 inhibitor -
Alternative names
- ARRY-142886
- Selumetinib
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Biological description
Potent, selective, non-ATP competitive MEK1/2 inhibitor (IC50 MEK1 = 14 nM). Also inhibits ERK1/2 phosphorylation.
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Purity
> 99% -
CAS Number
606143-52-6 -
Chemical structure
Properties
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Chemical name
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
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Molecular weight
457.69 -
Molecular formula
C17H15BrClFN4O3 -
PubChem identifier
10127622 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM and ethanol 4 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO -
Source
Synthetic
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Research areas
