AZD1152-HQPA, Aurora B kinase inhibitor (ab142049)
Key features and details
- Potent, selective Aurora B kinase inhibitor
- CAS Number: 722544-51-6
- Purity: > 99%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AZD1152-HQPA, Aurora B kinase inhibitor -
Description
Potent, selective Aurora B kinase inhibitor -
Biological description
Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo. -
Purity
> 99% -
CAS Number
722544-51-6 -
Chemical structure
Properties
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Chemical name
2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide -
Molecular weight
507.56 -
Molecular formula
C26H30FN7O3 -
PubChem identifier
16007391 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO -
Source
Synthetic
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Research areas