Serine derivative diazo compound with antibiotic, antifungal and antineoplastic properties. Structural analog of glutamine which competes with glutamine in binding to enzymes involved in purine biosynthesis. Inhibits the glutamine-dependent amidotransferases FGAM synthetase and glucosamine-6-phosphate isomerase. Inhibits the rate-limiting step of the hexosamine biosynthesis pathway (HBP) and irreversibly inhibits GGT1 (gamma-Glutamyltranspeptidase). Downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α. Protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway.

Soluble in water

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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Synthetic