Olcegepant, CGRP antagonist (ab269696)
Key features and details
- Potent and selective CGRP-1 receptor antagonist
- CAS Number: 204697-65-4
Soluble to 50 mM in DMSO
- Form / State: Solid
Overview
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Product name
Olcegepant, CGRP antagonist -
Description
Potent and selective CGRP-1 receptor antagonist -
Alternative names
- BIBN 4096
- BIBN4096BS
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Biological description
Potent (IC50 = 0.03 nM (human) and 6.4 nM (rat)) and selective CGRP-1 receptor antagonist. No significant activity observed against a panel of 75 other receptors. Potently inhibits neurogenic vasodilation.
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CAS Number
204697-65-4 -
Chemical structure
Properties
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Chemical name
1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine -
Molecular weight
869.66 -
Molecular formula
C38H47Br2N9O5 -
PubChem identifier
6918509 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble to 50 mM in DMSO
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Handling
Refer to SDS for further information.
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SMILES
C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)N[C@H](CC4=CC(=C(C(=C4)Br)O)Br)C(=O)N[C@@H](CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
Images
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Chemical Structure - Olcegepant, CGRP antagonist (ab269696)
Chemical structure of Olcegepant, CGRP antagonist, 204697-65-4