AZ 628, pan-Raf inhibitor (ab235573)
Key features and details
- Novel, potent, pan-Raf inhibitor for BRAF, BRAFV600E and c-Raf
- CAS Number: 878739-06-1
- Purity: > 98%
DMSO 90 mg/mL (199.32 mM)
Insoluble in water and ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AZ 628, pan-Raf inhibitor -
Description
Novel, potent, pan-Raf inhibitor for BRAF, BRAFV600E and c-Raf -
Biological description
AZ 628 is a novel, potent pan-Raf inhibitor. In cell-free assays it inhibits BRAF (IC50 = 105 nM), BRAFV600E (IC50 = 34 nM) and c-Raf (IC50 = 29 nM). It also inhibits VEGFR2, DDR2, Lyn, Flt1 and FMS. AZ 628 suppresses anchorage-dependent and -independent growth, gives rise to cell cycle arrest, and induces apoptosis in colon and melanoma cell lines harboring the B-Raf V600E mutation.
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Purity
> 98% -
CAS Number
878739-06-1 -
Chemical structure
Properties
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Chemical name
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
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Molecular weight
451.53 -
Molecular formula
C27H25N5O2 -
PubChem identifier
11676786 -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO 90 mg/mL (199.32 mM)
Insoluble in water and ethanol
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C -
Source
Synthetic
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Research areas
