Ascomycin, Calcineurin/PP2B inhibitor (ab141016)
Key features and details
- Calcineurin/PP2B inhibitor. Immunosuppressant and antifungal activity.
- CAS Number: 104987-12-4
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Streptomyces hygroscopicus var. ascomyceticus
Overview
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Product name
Ascomycin, Calcineurin/PP2B inhibitor -
Description
Calcineurin/PP2B inhibitor. Immunosuppressant and antifungal activity. -
Alternative names
- FK 520
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Biological description
Calcineurin/PP2B inhibitor (IC50 = 49 nM). Forms a FK-506 binding protein 12 (FKBP12) - Ascomycin -Calcineurin complex. Immunosuppressant and antifungal activity in vitro and in vivo.
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Purity
> 98% -
CAS Number
104987-12-4 -
Chemical structure
Properties
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Chemical name
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone -
Molecular weight
792.12 -
Molecular formula
C43H69NO12 -
PubChem identifier
6437370 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O[C@@H]1CC[C@H](C[C@H]1OC)\C=C(/C)[C@H]3OC(=O)[C@@H]2CCCN(C2)C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)CC(C)=C[C@@H](CC)C(=O)C[C@H](O)[C@H]3C)OC)[C@H](C[C@H]4C)OC -
Source
Streptomyces hygroscopicus var. ascomyceticus
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Research areas
