Aprepitant, hNK1 antagonist (ab269815)
Key features and details
- Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist
- CAS Number: 170729-80-3
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Aprepitant, hNK1 antagonist -
Description
Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist -
Alternative names
- MK-0869
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Biological description
Potent (IC50 = 0.09nM; Ki = 19 pM), long-acting and highly selective Neurokinin-1 (NK-1) receptor antagonist. Inhibits Substance P activity. Antiemetic. CNS penetrant.
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CAS Number
170729-80-3 -
Chemical structure
Properties
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Chemical name
5-[[(2R,3S)-2-[(1R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4- morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
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Molecular weight
534.43 -
Molecular formula
C23H21F7N4O3 -
PubChem identifier
135413536 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Toxic, refer to SDS for further information.
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SMILES
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F -
Source
Synthetic
Images
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Chemical Structure - Aprepitant, hNK1 antagonist (ab269815)
Chemical structure of Aprepitant, hNK1 antagonist, 170729-80-3
