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Aprepitant, hNK1 antagonist (ab269815)

Key features and details

  • Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist
  • CAS Number: 170729-80-3

  • Soluble in DMSO to 50 mM

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Aprepitant, hNK1 antagonist

  • Description

    Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist

  • Alternative names

    • MK-0869

  • Biological description

    Potent (IC50 = 0.09nM; Ki = 19 pM), long-acting and highly selective Neurokinin-1 (NK-1) receptor antagonist. Inhibits Substance P activity. Antiemetic. CNS penetrant.

  • CAS Number

    170729-80-3

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[[(2R,3S)-2-[(1R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4- morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

  • Molecular weight

    534.43

  • Molecular formula

    C23H21F7N4O3

  • PubChem identifier

    135413536

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 50 mM

  • Handling

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F

  • Source

    Synthetic

Images

  • Chemical Structure - Aprepitant, hNK1 antagonist (ab269815)
    Chemical Structure - Aprepitant, hNK1 antagonist (ab269815)

    Chemical structure of Aprepitant, hNK1 antagonist, 170729-80-3

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