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Anti-ST2 antibody [6B72] (ab196525)

Price and availability

452 304 ₸

Availability

Order now and get it on Thursday February 25, 2021

Key features and details

  • Mouse monoclonal [6B72] to ST2
  • Reacts with: Human
  • Isotype: IgG1

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Overview

  • Product name

    Anti-ST2 antibody [6B72]
    See all ST2 primary antibodies
  • Description

    Mouse monoclonal [6B72] to ST2
  • Host species

    Mouse
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human ST2 aa 1-350 (extracellular). (NP_057316.3 ).
    Database link: Q01638

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Lyophilized:Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml. Reconstituted antibody can be aliquoted and stored frozen at
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: 100% PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    6B72
  • Isotype

    IgG1
  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Cytokines
    • Interleukin
    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Cardiovascular
    • Heart
    • Hypertrophy
    • Other
    • Immunology
    • Innate Immunity
    • TLR Signaling

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant human ST2 protein (Fc Chimera Active) (ab219662)

Target

  • Function

    Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
  • Tissue specificity

    Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.
  • Sequence similarities

    Belongs to the interleukin-1 receptor family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 TIR domain.
  • Cellular localization

    Secreted and Cell membrane.
  • Target information above from: UniProt accession Q01638 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 9173 Human
    • Omim: 601203 Human
    • SwissProt: Q01638 Human
    • Unigene: 66 Human
    • Alternative names

      • DER-4 antibody
      • DER4 antibody
      • FIT 1 antibody
      • Growth stimulation expressed antibody
      • homolog of mouse growth stimulation-expressed antibody
      • Il1rl1 antibody
      • IL33R antibody
      • ILRL1_HUMAN antibody
      • Interleukin 1 receptor like 1 antibody
      • interleukin 1 receptor related protein antibody
      • Interleukin-1 receptor-like 1 antibody
      • Protein ST2 antibody
      • ST2 antibody
      • ST2L antibody
      • ST2V antibody
      • T1 antibody
      • T1 protein antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab196525? Please let us know so that we can cite the reference in this datasheet.

    ab196525 has been referenced in 1 publication.

    • Al-Sajee D  et al. Expression of IL-33 and TSLP and Their Receptors in Asthmatic Airways after Inhaled Allergen Challenge. Am J Respir Crit Care Med 198:805-807 (2018). PubMed: 29733677

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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