rSec6 is an 87 kDa rat homolog of yeast Sec6p, a protein involved in protein transport between the Golgi apparatus and the plasma membrane2. In yeast, Sec6p is part of a high molecular weight complex which includes Sec8p and Sec15p, that associates with the ras-like GTP binding protein Sec4p 2. An analogous 17S complex in rat brain was found to contain eight novel proteins, including rSec6 and rSec8, with a combined molecular weight of 734 kDa 3. Membrane associated rSec6/8 complex has been shown to coimmunoprecipitate with syntaxin, and is ubiquitously expressed, further ev idence that this complex is involved in the mammalian exocyst complex.

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