Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)
Key features and details
- Rabbit polyclonal to KMT2C / MLL3 (acetyl K2809)
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-KMT2C / MLL3 (acetyl K2809) antibody -
Description
Rabbit polyclonal to KMT2C / MLL3 (acetyl K2809)This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »
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Host species
Rabbit -
Specificity
In ELISA, ab40973 KMT2C / MLL3 (acetyl K2809) cross reacts 12% with the non modified KMT2C / MLL3 protein.
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Tested Applications & Species
See all applications and species dataApplication Species ELISA Human
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Immunogen
Synthetic peptide conjugated to KLH derived from within residues 2800 - 2850 of Human KMT2C/ MLL3.
Read Abcam's proprietary immunogen policy (Peptide available as ab41903.)
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration
Concentration information loading...Purity
Immunogen affinity purifiedClonality
PolyclonalIsotype
IgGResearch areas
Associated products
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Compatible Secondaries
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Control Peptide
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Isotype control
Applications
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use
GuaranteedTested applications are guaranteed to work and covered by our Abpromise guarantee.
PredictedPredicted to work for this combination of applications and species but not guaranteed.
IncompatibleDoes not work for this combination of applications and species.
Application Species ELISA HumanApplication Abreviews Notes ELISA Use at an assay dependent concentration.In ELISA, ab40973 KMT2C / MLL3 (acetyl K2809) cross reacts 12% with the non modified KMT2C / MLL3 protein.
Notes ELISA
Use at an assay dependent concentration.In ELISA, ab40973 KMT2C / MLL3 (acetyl K2809) cross reacts 12% with the non modified KMT2C / MLL3 protein.
Target
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Function
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. -
Tissue specificity
Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. -
Sequence similarities
Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
Contains 1 A.T hook DNA-binding domain.
Contains 1 DHHC-type zinc finger.
Contains 6 PHD-type zinc fingers.
Contains 1 post-SET domain.
Contains 1 RING-type zinc finger.
Contains 1 SET domain. -
Domain
The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 58508 Human
- Omim: 606833 Human
- SwissProt: Q8NEZ4 Human
- Unigene: 647120 Human
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Alternative names
- Histone-lysine N-methyltransferase MLL3 antibody
- Homologous to ALR protein antibody
- KMT2C antibody
see all
Images
This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.-
ELISA - Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)
This antibody gave a positive result in ELISA against the immunizing peptide (Human KMT2C / MLL3 (acetyl K2809) peptide, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab40973 has not yet been referenced specifically in any publications.
Images
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ELISA - Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)
This antibody gave a positive result in ELISA against the immunizing peptide (Human KMT2C / MLL3 (acetyl K2809) peptide, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.