Antibodies, Proteins, Kits and Reagents for Life Science

291 484 ₸ Product size

200 µl 291 484 ₸

Order now and get it on Thursday February 25, 2021

Key features and details

Product name

Anti-Iroquois homeobox protein 3/IRX3 antibody
See all Iroquois homeobox protein 3/IRX3 primary antibodies
Description

Rabbit polyclonal to Iroquois homeobox protein 3/IRX3
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Mouse

See all applications and species data
Immunogen

Synthetic peptide corresponding to Mouse Iroquois homeobox protein 3/IRX3 aa 150-250 conjugated to keyhole limpet haemocyanin.
(Peptide available as ab26905, ab26906)
General notes

This product was previously labelled as Iroquois homeobox protein 3

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

Batches of this product that have a concentration
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Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab25703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Mouse
All applications	Chicken Human Xenopus laevis Zebrafish

Application	Abreviews	Notes
WB		Use a concentration of 2 µg/ml. Detects a band of approximately 52, 55 kDa (predicted molecular weight: 52 kDa).

Notes
WB Use a concentration of 2 µg/ml. Detects a band of approximately 52, 55 kDa (predicted molecular weight: 52 kDa).

Function

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells.
Sequence similarities

Belongs to the TALE/IRO homeobox family.
Contains 1 homeobox DNA-binding domain.
Cellular localization

Nucleus.
Target information above from: UniProt accession P78415 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
Database links
- Entrez Gene: 408181 Chicken
- Entrez Gene: 79191 Human
- Entrez Gene: 16373 Mouse
- Entrez Gene: 399365 Xenopus laevis
- Entrez Gene: 30520 Zebrafish
- Omim: 612985 Human
- SwissProt: P78415 Human
- SwissProt: P81067 Mouse
- SwissProt: O42261 Xenopus laevis
- Unigene: 499205 Human
- Unigene: 238044 Mouse
- Unigene: 4522 Xenopus laevis
see all
Alternative names
- AI894186 antibody
- Homeodomain protein IRXB1 antibody
- Iroquois class homeodomain protein IRX 1 antibody
- Iroquois homeobox 3 antibody
- Iroquois homeobox protein 3 antibody
- Iroquois-class homeodomain protein irx-3 antibody
- IRX 1 antibody
- irx3 antibody
- IRX3_HUMAN antibody
- IRXB1 antibody
see all

Publishing research using ab25703? Please let us know so that we can cite the reference in this datasheet.

ab25703 has been referenced in 4 publications.

Zou Y et al. IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk. EBioMedicine 24:64-75 (2017). PubMed: 28988979
Wang P et al. Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma. Oncol Rep 36:247-52 (2016). PubMed: 27222047
Shekhar A et al. Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest 126:4444-4459 (2016). IHC-Fr ; Mouse . PubMed: 27775552
Gaborit N et al. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development 139:4007-19 (2012). ChIP ; Mouse . PubMed: 22992950