Anti-FLIP delta + gamma antibody

Rabbit polyclonal to FLIP delta + gamma

Rabbit

This antibody recognizes human and murine FLIP gamma and FLIP delta It does not recognise FLIP alpha and FLIP beta.

Suitable for: WB, ICC/IFmore details

Reacts with: Mouse, Human

Synthetic peptide:

QKSLKDPSNNFRMITPYAH

, corresponding to C terminal amino acids 191/209 of Human FLIP delta + gamma. (Peptide available as ab8458).

• WB: HeLa, Jurkat , THP-1, A431, K562, and NIH3T3 cell lysates. ICC/IF: HeLa and Jurkat cells. ICC: HeLa and Jurkat cells.

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS

Affinity purified

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and c-FLIPs, respectively (1,2). The human FLIPs were also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH, CLARP and usurpin (3-7). FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and –10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1. Four splice variants of c-FLIPs have been identified and termed FLIP alpha, beta, gamma, and delta, respectively (8).

Polyclonal

IgG

unknown

• Cell Biology
• Apoptosis
• Extracellular Signals
• Death Ligands

• Cell Biology
• Apoptosis
• Intracellular
• Caspases etc
• Inhibitors