Anti-alpha A Crystallin/CRYAA antibody
See all alpha A Crystallin/CRYAA primary antibodies

Rabbit polyclonal to alpha A Crystallin/CRYAA

Rabbit

This antibody is not expected to detect the non-phosphorylated form of the protein. Please contact our Scientific Support team for more information.

Reacts with: Rat, Cow
Predicted to work with: Sheep, Rabbit, Horse, Guinea pig, Hamster, Cat, Dog, Human, Pig, Rhesus monkey, Elephant

Full length native protein (purified) corresponding to Cow alpha A Crystallin/CRYAA (phospho ). Purified alpha-A Crystallin from bovine lens.

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: PBS, 3% BSA

Immunogen affinity purified

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease where it accumulates in brain cells of those afflicted.

Polyclonal

IgG

• Signal Transduction
• Protein Trafficking
• Chaperones
• Heat Shock Proteins

• Tags & Cell Markers
• Cell Type Markers
• Other Cell Types

• Neuroscience
• Sensory System
• Visual system