Andrastin A, PFTase inhibitor (ab144836)
Key features and details
- Mycotoxin. PFTase inhibitor.
- CAS Number: 174232-42-9
- Purity: > 95%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Aspergillus fumigatus
Overview
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Product name
Andrastin A, PFTase inhibitor -
Description
Mycotoxin. PFTase inhibitor. -
Biological description
Mycotoxin. PFTase inhibitor. Potently inhibits interaction with P-glycoprotein (IC50 = 100 nM, [3H]azidopine binding in VJ-300 cells). Inhibits the efflux of antitumor agents in drug resistant cells. Increases intracellular accumulation of Vincristine (ab120226). -
Purity
> 95% -
CAS Number
174232-42-9 -
Chemical structure
Properties
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Chemical name
Methyl (3S,5R,8S,9R,10S,13R,14R)-3-acetyloxy-10-formyl-4,4,8,12,13,16-hexamethyl-15,17-dioxo-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-14-carboxylate -
Molecular weight
486.60 -
Molecular formula
C28H38O7 -
PubChem identifier
6712564 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(=O)[C@@]2(C(=C[C@@H]3[C@@]([C@@]2(C1=O)C(=O)OC)(CC[C@H]4[C@]3(CC[C@@H](C4(C)C)OC(=O)C)C=O)C)C)C -
Source
Aspergillus fumigatus
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Research areas
