Amylin (human), Endogenous peptide (ab142398)
Key features and details
- Endogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist.
- CAS Number: 122384-88-7
- Purity: > 95%
- Soluble in water (5 mg/mL)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Amylin (human), Endogenous peptide -
Description
Endogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist. -
Alternative names
- Islet amyloid polypeptide (IAPP)
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Biological description
Endogenous peptide. Potent amylin, calcitonin (EC50 = 0.67 nM), CGRP and adrenomedullin receptor agonist. Potently inhibits insulin-stimulated glucose uptake in skeletal muscle cells (IC50 = 12 pM). Implicated in type II diabetes. Active in vivo. Rat (ab142399) and feline (ab142397) amylin also available. -
Purity
> 95% -
CAS Number
122384-88-7 -
Chemical structure
Properties
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Molecular weight
3903.40 -
Molecular formula
C165H261N51O55S2 -
Sequence
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Modifications: C-terminal amide; Disulfide bonds: 2-7) -
PubChem identifier
16132430 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water (5 mg/mL) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
