Amsacrine, DNA topoisomerase II inhibitor (ab142742)
Key features and details
- DNA topoisomerase II inhibitor
- CAS Number: 51264-14-3
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Amsacrine, DNA topoisomerase II inhibitor -
Description
DNA topoisomerase II inhibitor -
Biological description
DNA topoisomerase II inhibitor. Antineoplastic agent. Intercalating planar polycyclic aromatic molecule which is active against a number of tumours in mice. Active in vivo.
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Purity
> 98% -
CAS Number
51264-14-3 -
Chemical structure
Properties
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Chemical name
N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide -
Molecular weight
393.46 -
Molecular formula
C21H19N3O3S -
PubChem identifier
2179 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42 -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- DNA / RNA
- DNA Damage & Repair
- DNA Damage Response
- DNA Damage Recognition
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases