Aminopurvalanol A, cyclin-dependent kinase inhibitor (ab145052)
Key features and details
- Potent, cell-permeable cyclin-dependent kinase inhibitor
- CAS Number: 220792-57-4
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Aminopurvalanol A, cyclin-dependent kinase inhibitor -
Description
Potent, cell-permeable cyclin-dependent kinase inhibitor -
Biological description
Potent, cell-permeable cyclin-dependent kinase inhibitor (IC50 values are 33 (cdk1/cyclin B), 33 (cdk2/cyclin A), 28 (cdk2/cyclin E) and 20 nM (cdk5/p35)). Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM). Induces cell cycle arrest at G2/M phase (IC50 = 1.25 μM). Shows apoptotic effects.
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Purity
> 99% -
CAS Number
220792-57-4 -
Chemical structure
Properties
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Chemical name
(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol -
Molecular weight
403.91 -
Molecular formula
C19H26ClN7O -
PubChem identifier
6604931 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(CO)Nc2nc(Nc1cc(N)cc(Cl)c1)c3ncn(c3n2)C(C)C -
Source
Synthetic
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Research areas
