AMG 9810, TRPV1 receptor antagonist (ab145874)
Key features and details
- Potent, selective, competitive vanilloid TRPV1 receptor antagonist
- CAS Number: 545395-94-6
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AMG 9810, TRPV1 receptor antagonist -
Description
Potent, selective, competitive vanilloid TRPV1 receptor antagonist -
Biological description
Potent, selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Active in vitro and in vivo.
See similar compounds -
Purity
> 99% -
CAS Number
545395-94-6 -
Chemical structure
Properties
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Chemical name
(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide -
Molecular weight
337.42 -
Molecular formula
C21H23NO3 -
PubChem identifier
680502 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)C1=CC=C(C=C1)/C=C/C(=O)NC2=CC3=C(C=C2)OCCO3 -
Source
Synthetic
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Research areas
