Ajmalicine (Raubasine), alpha1-adrenoceptor antagonist (ab145408)
Key features and details
- Selective α1-adrenoceptor antagonist. Reversible non-competitive nicotine receptor antagonist.
- CAS Number: 483-04-5
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ajmalicine (Raubasine), alpha1-adrenoceptor antagonist -
Description
Selective α1-adrenoceptor antagonist. Reversible non-competitive nicotine receptor antagonist. -
Biological description
Selective competitive α1-adrenoceptor antagonist (pA2 = 6.57, noradrenaline). Reversible non-competitive nicotine receptor antagonist (IC50 = 72.3 μM). Competitively blocks the inhibitory effect of clonidine. Shows antihypertensive effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
483-04-5 -
Chemical structure
Properties
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Chemical name
(19α)-16,17-Didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester -
Molecular weight
352.43 -
Molecular formula
C21H24N2O3 -
PubChem identifier
441975 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]1[C@H]2CN3CCC4=C([C@@H]3C[C@@H]2C(=CO1)C(=O)OC)NC5=CC=CC=C45 -
Source
Synthetic
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Research areas