AG 1478, EGF receptor tyrosine kinase inhibitor (ab141438)
Key features and details
- Selective EGF receptor tyrosine kinase inhibitor
- CAS Number: 175178-82-2
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AG 1478, EGF receptor tyrosine kinase inhibitor -
Description
Selective EGF receptor tyrosine kinase inhibitor -
Biological description
Selective EGF receptor tyrosine kinase inhibitor (Ki = 10 nM). Supresses proliferation and cell-cycle progression. Cell-permeable and active in vivo.
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Purity
> 98% -
CAS Number
175178-82-2 -
Chemical structure
Properties
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Chemical name
4-[(3-Chlorophenyl)methyl]-6,7-dimethoxyquinazoline -
Molecular weight
315.75 -
Molecular formula
C16H14ClN3O2 -
PubChem identifier
53429216 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)CC3=CC(=CC=C3)Cl)OC -
Source
Synthetic
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Research areas
