Abexinostat (ab254242)
Key features and details
- Broad-spectrum histone deacytylase (HDAC) inhibitor.
- CAS Number: 783355-60-2
- Purity: > 96%
Soluble in DMSO to 200 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Abexinostat -
Description
Broad-spectrum histone deacytylase (HDAC) inhibitor. -
Biological description
Broad spectrum phenyl hydroamic acid inhibitor of HDAC (histone deacetylase). Nanomolar potency in cell-free assays (HDAC1 Ki = 7nM; HDAC2 Ki = 19 nM; HDAC3 Ki = 8.2 nM; HDAC6 Ki = 17nM; HDAC8 IC50 = 280 nM; HDAC10 IC50 = 24 nM). Inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Inhibits homologous recombination (HR) activity by inhibiting the expression of RAD51.
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Purity
> 96% -
General notes
Protect from air and light.
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CAS Number
783355-60-2 -
Chemical structure
Properties
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Chemical name
3-[(Dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
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Molecular weight
397.43 -
Molecular formula
C21H23N3O5 -
PubChem identifier
11749858 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 200 mM
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO -
Source
Synthetic
