A 83-01 (DMSO solution, sterile-filtered), ALK4, 5 and 7 kinase inhibitor (ab146622)
Key features and details
- Potent ALK4, 5 and 7 kinase inhibitor. TGF-β1 inhibitor.
- CAS Number: 909910-43-6
- Purity: > 98%
- Supplied in DMSO (5 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
A 83-01 (DMSO solution, sterile-filtered), ALK4, 5 and 7 kinase inhibitor -
Description
Potent ALK4, 5 and 7 kinase inhibitor. TGF-β1 inhibitor. -
Biological description
Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
Also available as a solid (ab142092). -
Purity
> 98% -
CAS Number
909910-43-6 -
Chemical structure
Properties
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Chemical name
3-(6-Methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide -
Molecular weight
421.52 -
Molecular formula
C25H19N5S -
PubChem identifier
16218924 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (5 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 -
Source
Synthetic
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Research areas
