6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631)
Key features and details
- High affinity aryl hydrocarbon receptor ligand
- CAS Number: 172922-91-7
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand -
Description
High affinity aryl hydrocarbon receptor ligand -
Alternative names
- FICZ
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Biological description
High affinity aryl hydrocarbon receptor ligand. Proposed endogenous AhR ligand. -
Purity
> 95% -
CAS Number
172922-91-7 -
Chemical structure
Properties
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Chemical name
5,11-Dihydroindolo[3,2-b]carbazole-12-carbaldehyde -
Molecular weight
284.30 -
Molecular formula
C19H12N2O -
PubChem identifier
1863 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C3=CC4=C(C5=CC=CC=C5N4)C(=C3N2)C=O -
Source
Synthetic
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Research areas
Images
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Functional Studies - 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand (ab141631) Bunaciu et al PLoS One. 2015; 10(8): e0135668. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
FICZ upregulates Cyp1A1 expression.
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF as indicated for 2 h and 48 h. At 2 h post treatment, FICZ upregulates Cyp1A1 expression in HL-60 cells, reaching significance for RA+FICZ vs C (p = 0.0029) and vs RA (p = 0.0045) and α-NF+FICZ+RA vs C (p = 0.0086) and vs RA (p = 0.0134).
FICZ = 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand.
(From Figure 4 of Bunaciu et al).