3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor (ab145628)
Key features and details
- Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor.
- CAS Number: 120964-45-6
- Purity: > 98%
- Soluble in water to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor -
Description
Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor. -
Alternative names
- DZNep hydrochloride
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Biological description
Lysine methyltransferase EZH2 inhibitor. Competitive s-adenosylhomocysteine hydrolase inhibitor (Ki = 50 pM). DZNep acts as an epigenetic modifier, specifically blocking trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4. (Miranda et al., Tan et al., Tseng et al.) Induces cancer cell selective apoptosis. Adenosine (ab120498) analog. Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.).
Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.). Enables chemical reprogramming of mouse embryonic fibroblasts iPSC, in combination with CHIR99021 (ab120890), Forskolin (ab120058), Valproic Acid (ab120745), Tranylcypromine (ab120606) and E-616452 (RepSox ab142139), by increasing OCT4 expression at later stages of reprogramming (Hou et al.). -
Purity
> 98% -
CAS Number
120964-45-6 -
Chemical structure
Properties
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Chemical name
5-(4-Aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol hydrochloride -
Molecular weight
298.73 -
Molecular formula
C12H14N4O3.HCl -
PubChem identifier
358176 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl -
Source
Synthetic
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Research areas
