24(S)-Hydroxycholesterol, Endogenous LXR agonist (ab141632)
Key features and details
- Endogenous LXR agonist
- CAS Number: 474-73-7
- Purity: > 98%
- Soluble in DMSO to 25 mM and in ethanol to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
24(S)-Hydroxycholesterol, Endogenous LXR agonist -
Description
Endogenous LXR agonist -
Biological description
Endogenous agonist for LXR (EC50 values are 4 μM and 3 μM at LXRα and LXRβ respectively). Involved in cholesterol homeostasis. Induces neuronal cell death by necroptosis, a form of programmed necrosis. -
Purity
> 98% -
CAS Number
474-73-7 -
Chemical structure
Properties
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Chemical name
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-Hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol -
Molecular weight
402.70 -
Molecular formula
C27H46O2 -
PubChem identifier
121948 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
