1,5-Isoquinolinediol, PARP-1 inhibitor (ab144285)
Key features and details
- Potent PARP-1 inhibitor
- CAS Number: 5154-02-9
- Purity: > 98%
- Soluble in ethanol to 100 mM (with warming), in DMSO to 100 mM and in 0.1 N NaOH to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
1,5-Isoquinolinediol, PARP-1 inhibitor -
Description
Potent PARP-1 inhibitor -
Biological description
Potent PARP-1 inhibitor (IC50 = 390 nM). Inhibits iNOS. Attenuates diabetes-induced upregulation of PARP, ROS, ERK1/2 phosphorylation, cleaved caspase-3 and downregulation of BDNF, synaptophysin, and GS. Shows neuroprotective effects in vivo. -
Purity
> 98% -
CAS Number
5154-02-9 -
Chemical structure
Properties
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Chemical name
5-hydroxy-2H-isoquinolin-1-one -
Molecular weight
161.16 -
Molecular formula
C9H7NO2 -
PubChem identifier
1340 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. -
Solubility overview
Soluble in ethanol to 100 mM (with warming), in DMSO to 100 mM and in 0.1 N NaOH to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=CNC2=O)C(=C1)O -
Source
Synthetic
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Research areas
