ZSTK474, ATP-competitve PI3K inhibitor (ab146194)
Key features and details
- Potent, ATP-competitve PI3K inhibitor
- CAS Number: 475110-96-4
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZSTK474, ATP-competitve PI3K inhibitor -
Description
Potent, ATP-competitve PI3K inhibitor -
Biological description
Potent, ATP-competitive PI3K inhibitor (IC50 values are 5, 16, 44 and 49 nM for PI3Kδ, PI3Kα, PI3Kβ and PI3Kγ respectively). Induces G1-phase arrest but not apoptosis. Shows potent antiproliferative effects. Shows antitumor effects in vivo. Orally active.
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CAS Number
475110-96-4 -
Chemical structure
Properties
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Chemical name
4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine -
Molecular weight
417.41 -
Molecular formula
C19H21F2N7O2 -
PubChem identifier
11647372 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5 -
Source
Synthetic
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Research areas
