ZM 449829, JAK3 inhibitor (ab145881)
Key features and details
- Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor.
- CAS Number: 4452-06-6
- Purity: > 98%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZM 449829, JAK3 inhibitor -
Description
Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor. -
Biological description
Potent, selective, ATP-competitive JAK3 inhibitor (pIC50 values are 6.8, 5.0, 4.7, and 50 = 10 nM). Inhibits STAT5 phosphorylation and T cell proliferation. -
Purity
> 98% -
CAS Number
4452-06-6 -
Chemical structure
Properties
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Chemical name
1-(2-Naphthalenyl)-2-propen-1-one -
Molecular weight
182.22 -
Molecular formula
C13H10O -
PubChem identifier
3799 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C=CC(=O)C1=CC2=CC=CC=C2C=C1 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
