ZD7288, Sino-atrial node function modulator (ab120102)
Key features and details
- Sino-atrial node function modulator
- CAS Number: 133059-99-1
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZD7288, Sino-atrial node function modulator -
Description
Sino-atrial node function modulator -
Alternative names
- ICI D7288
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Biological description
Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
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Purity
> 98% -
CAS Number
133059-99-1 -
Chemical structure
Properties
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Chemical name
4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride -
Molecular weight
292.81 -
Molecular formula
C15H21ClN4 -
PubChem identifier
123983 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].C[n+]1c(NC)cc(nc1C)N(CC)c2ccccc2 -
Source
Synthetic
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Research areas
Images
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Cellular activation - ZD7288, Sino-atrial node function modulator (ab120102) Image from Glasgow D, et al. Plos One, 8(3), e58901. Fig 6B,; doi: 10.1371/journal.pone.0058901
Membrane currents during slow voltage ramps from ?120 mV to ?40 mV in the presence of TTX (0.5 µM) and ZD7288 (50 µM), and during subsequent bath application of CCh (light grey line; 50 µM; B1) show that cholinergic receptor activation induces an inward current at voltages near resting membrane potential that reverses around ?76 mV, consistent the blockade of outward K+ currents. The application of CCh occluded additional inward current during subsequent bath application of XE-991 (dark grey line; 10 µM) sµggesting that CCh depolarizes PaS neurons in part by suppression of the M-current. Current subtractions show that CCh blocks an outward current that reverses at ?83.3±7.0 mV (black line; B2), and also occluded membrane currents normally induced by XE-991 (grey line).