Z-WEHD-FMK, caspase-1, caspase-5 and cathepsin B inhibitor (ab142027)
Key features and details
- Cell permeable inhibitor of caspase-1, caspase-5 and cathepsin B.
- Purity: > 99%
Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Z-WEHD-FMK, caspase-1, caspase-5 and cathepsin B inhibitor -
Description
Cell permeable inhibitor of caspase-1, caspase-5 and cathepsin B. -
Biological description
Cell permeable inhibitor of caspase-1, caspase-5 and cathepsin B (IC50 = 6 µM). Inhibits apoptosis in multiple biological systems. -
Purity
> 99% -
Chemical structure
Properties
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Molecular weight
763.78 -
Molecular formula
C37H42FN7O10 -
Sequence
WEHD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
44134610 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (10 mM)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4 -
Source
Synthetic
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Research areas