Z-LE(OMe)VD(OMe)-FMK, derivative of Z-LEVD-FMK (ab120489)
Key features and details
- Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Z-LE(OMe)VD(OMe)-FMK, derivative of Z-LEVD-FMK -
Description
Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK -
Alternative names
- Z-LEVD-FMK (cell permeable)
-
Biological description
Methylated, cell-permeable derivative of the caspase-4 inhibitor Z-Leu-Glu-Val-Asp-FMK (Z-LEVD-FMK). Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
-
Chemical structure
Properties
-
Molecular weight
652.72 -
Molecular formula
C31H45FN4O10 -
Sequence
LEVD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
25108689 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 20 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
FCC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(C)C -
Source
Synthetic
-
Research areas
