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Z-IETD-FMK, Caspase-8 inhibitor (ab141382)

Key features and details

  • Caspase-8 inhibitor
  • CAS Number:
  • Purity: > 99%
  • Form / State: Lyophilized
  • Source: Synthetic

Overview

  • Product name

    Z-IETD-FMK, Caspase-8 inhibitor

  • Description

    Caspase-8 inhibitor

  • Purity

    > 99%

  • Chemical structure

    Chemical Structure

Properties

Images

  • Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (ab141382)
    ab13847 staining active caspase 3 in SKNSH cells treated with Z-IETD-FMK (ab141382), by ICC/IF. Decrease in active caspase 3 expression correlates with increased concentration of Z-IETD-FMK, as described in literature.
    The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141382 (Z-IETD-FMK) in DMSO. After this incupation 10 µM of camptothecin (ab120115) was added to all samples and the cells were incubated for further 24 hours. The samples were then fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13847 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DA

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