VX-745, p38 alpha MAPK inhibitor (ab230367)
Key features and details
- Potent, selective p38 alpha MAPK inhibitor
- CAS Number: 209410-46-8
VX-745 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). We do not recommend storing the aqueous solution for more than one day.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VX-745, p38 alpha MAPK inhibitor -
Description
Potent, selective p38 alpha MAPK inhibitor -
Alternative names
- Neflamapimod
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Biological description
Potent, selective p38 alpha MAPK inhibitor (IC50 = 10 nM), with 20-fold selectivity over p38 beta and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3.
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CAS Number
209410-46-8 -
Chemical structure
Properties
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Chemical name
5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one
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Molecular weight
436.26 -
Molecular formula
C19H9Cl2F2N3OS -
PubChem identifier
3038525 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
VX-745 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). We do not recommend storing the aqueous solution for more than one day.
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Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
ClC1=C(C2=C(C=CC(SC3=CC=C(F)C=C3F)=N4)N4C=NC2=O)C(Cl)=CC=C1 -
Source
Synthetic
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Research areas
