Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist (ab142167)
Key features and details
- Selective mitotic microtubule antagonist
- CAS Number: 125317-39-7
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Vinorelbine tartrate (Navelbine), mitotic microtubule antagonist -
Description
Selective mitotic microtubule antagonist -
Biological description
Selective mitotic microtubule antagonist. Inhibits multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells). Blocks metaphase/anaphase transition (IC50 = 3.8 nM). Active in vivo. Orally active. Shows antimitotic and antitumor activity. -
Purity
> 98% -
CAS Number
125317-39-7 -
Chemical structure
Properties
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Chemical name
3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine ditartrate -
Molecular weight
1079.11 -
Molecular formula
C45H54N4O8.2C4H6O6 -
PubChem identifier
607791 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O -
Source
Synthetic
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Research areas
