Vandetanib, VEGFR2 tyrosine kinase inhibitor (ab142099)
Key features and details
- Orally available, potent VEGFR2 tyrosine kinase inhibitor
- CAS Number: 443913-73-3
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Vandetanib, VEGFR2 tyrosine kinase inhibitor -
Description
Orally available, potent VEGFR2 tyrosine kinase inhibitor -
Alternative names
- 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
- Caprelsa®
- CH 331
see all -
Biological description
Orally available, potent VEGFR2 tyrosine kinase inhibitor (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Displays anti-angiogenesis activity.
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Purity
> 98% -
CAS Number
443913-73-3 -
Chemical structure
Properties
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Chemical name
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy] quinazolin-4-amine -
Molecular weight
475.35 -
Molecular formula
C22H24BrFN4O2 -
PubChem identifier
3081361 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC -
Source
Synthetic
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Research areas
