Triciribine, inhibitor of Akt activation (ab120936)
Key features and details
- Selective, potent inhibitor of Akt activation
- CAS Number: 35943-35-2
- Purity: > 98%
- Soluble in DMSO to 75 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Triciribine, inhibitor of Akt activation -
Description
Selective, potent inhibitor of Akt activation -
Alternative names
- API 2
- NSC 154020
- TCN
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Biological description
Cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation and signalling of Akt. Selective over PKC, PKA, SGK and p38 pathways. Induces cell growth arrest and apoptosis in vitro. -
Purity
> 98% -
CAS Number
35943-35-2 -
Chemical structure
Properties
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Chemical name
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine -
Molecular weight
320.31 -
Molecular formula
C13H16N6O4 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC[C@H]1O[C@H](C(O)C1O)n1cc2c(N)nn(C)c3ncnc1c23 -
Source
Synthetic
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Research areas
