Trichostatin A, histone deacetylase inhibitor (ab120850)
Key features and details
- Potent, selective histone deacetylase inhibitor
- CAS Number: 58880-19-6
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
Trichostatin A, histone deacetylase inhibitor -
Description
Potent, selective histone deacetylase inhibitor -
Biological description
Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
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Purity
> 98% -
CAS Number
58880-19-6 -
Chemical structure
Properties
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Chemical name
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide -
Molecular weight
302.37 -
Molecular formula
C17H22N2O3 -
PubChem identifier
444732 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C -
Source
Streptomyces sp.
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Research areas
Images
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Functional Studies - Trichostatin A, histone deacetylase inhibitor (ab120850)Trichostatin A inhibits histone deacetylases in NIH/3T3 cells.
Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.