Trichostatin A (DMSO solution), histone deacetylase inhibitor (ab146598)
Key features and details
- Potent, selective histone deacetylase inhibitor
- CAS Number: 58880-19-6
- Purity: > 99%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Trichostatin A (DMSO solution), histone deacetylase inhibitor -
Description
Potent, selective histone deacetylase inhibitor -
Biological description
Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
Also available as a solid (ab120850). -
Purity
> 99% -
CAS Number
58880-19-6 -
Chemical structure
Properties
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Chemical name
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide -
Molecular weight
302.37 -
Molecular formula
C17H22N2O3 -
PubChem identifier
444732 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Co-activators/co-repressors
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
