TIC10 (ONC201), TRAIL activator (ab145750)
Key features and details
- TRAIL activator
- CAS Number: 41276-02-2
- Purity: > 99%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TIC10 (ONC201), TRAIL activator -
Description
TRAIL activator -
Alternative names
- ONC201
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Biological description
TRAIL activator. Induces TRAIL via Akt and ERK inactivation. Induces apoptosis in cancer cells and healthy cells. Shows antitumor effects in vivo. Blood-brain barrier permeable. -
Purity
> 99% -
CAS Number
41276-02-2 -
Chemical structure
Properties
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Chemical name
2,6,7,8,9,10-Hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one -
Molecular weight
386.49 -
Molecular formula
C24H26N4O -
PubChem identifier
336423 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5 -
Source
Synthetic
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Research areas