Terfenadine, K+ channel blocker. H1 antagonist. (ab120270)
Key features and details
- K+ channel blocker. H1 antagonist.
- CAS Number: 50679-08-8
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Terfenadine, K+ channel blocker. H1 antagonist. -
Description
K+ channel blocker. H1 antagonist. -
Biological description
K+ channel blocker (Kv11.1). Blocks ATP-sensitive K+ channels (IC50 = 1.2 μM). H1 receptor antagonist.
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Purity
> 98% -
CAS Number
50679-08-8 -
Chemical structure
Images
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Functional Studies - Terfenadine, K+ channel blocker. H1 antagonist. (ab120270)ab2893 staining γH2A.X in MALME-3M cells treated with terfenadine (ab120270), by ICC/IF. Increase of γH2A.X nuclear expression correlates with increased concentration of terfenadine, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120270 (terfenadine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2893 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.