TCS 359, FLT3 receptor tyrosine kinase inhibitor (ab141268)
Key features and details
- Potent FLT3 receptor tyrosine kinase inhibitor
- CAS Number: 301305-73-7
- Purity: > 99%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TCS 359, FLT3 receptor tyrosine kinase inhibitor -
Description
Potent FLT3 receptor tyrosine kinase inhibitor -
Biological description
Potent FLT3 receptor tyrosine kinase inhibitor (IC50 = 42 nM). Selective over 22 other kinases. Shows antiproliferative effects (IC50 = 340 nM for Human acute myelocytic leukemia MV4-11 cells).
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Purity
> 99% -
CAS Number
301305-73-7 -
Chemical structure
Properties
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Chemical name
2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide -
Molecular weight
360.43 -
Molecular formula
C18H20N2O4S -
PubChem identifier
1048845 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1OC)C(=O)Nc3sc2CCCCc2c3C(N)=O -
Source
Synthetic
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Research areas
